A study conducted at the University of São Paulo (USP) in Brazil and described in an article published in the journal Scientific Reports shows that anti-inflammatory drugs commonly taken by children may be associated with dental enamel defects (DEDs), currently seen in about 20% of children worldwide.

The authors, who are affiliated with the Ribeirão Preto Dental School (FORP-USP) and School of Pharmaceutical Sciences (FCFRP-USP), investigated the effects of celecoxib and indomethacin, non-steroidal anti-inflammatory drugs (NSAIDs) classified by the World Health Organization (WHO) as the first step on the analgesic ladder, alongside paracetamol.