{"version":"1.0","provider_name":"\u0647\u0644\u0633\u0627 \u067e\u0627\u0631\u062a","provider_url":"https:\/\/www.helsapart.com\/fa\/","author_name":"admin","author_url":"https:\/\/www.helsapart.com\/fa\/author\/admin\/","title":"ORAI1 Fuels Oral Cancers and Generates Pain - \u0647\u0644\u0633\u0627 \u067e\u0627\u0631\u062a","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"m6U9kyxSJ1\"><a href=\"https:\/\/www.helsapart.com\/fa\/orai1-fuels-oral-cancers-and-generates-pain\/\">ORAI1 Fuels Oral Cancers and Generates Pain<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/www.helsapart.com\/fa\/orai1-fuels-oral-cancers-and-generates-pain\/embed\/#?secret=m6U9kyxSJ1\" width=\"600\" height=\"338\" title=\"&#8220;ORAI1 Fuels Oral Cancers and Generates Pain&#8221; &#8212; \u0647\u0644\u0633\u0627 \u067e\u0627\u0631\u062a\" data-secret=\"m6U9kyxSJ1\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/www.helsapart.com\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","thumbnail_url":"https:\/\/www.helsapart.com\/wp-content\/uploads\/2023\/09\/iStock-916411170-e1694092783848.jpg","thumbnail_width":2048,"thumbnail_height":1152,"description":"An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and\u00a0generates pain, according to a new study\u00a0published in\u00a0Science Signaling\u00a0led by researchers at NYU College of Dentistry.\u00a0Targeting this protein\u2014the ORAI1 calcium channel\u2014could provide a new approach to treating oral cancer, which causes persistent pain that worsens as it progresses.\u00a0\u201cOur results show that the ORAI1 channel fuels the growth of oral cancer tumors and produces an abundance of molecules that, once secreted, interact with neurons resulting in an increased sensitivity to pain,\u201d said Ga-Yeon Son, a postdoctoral fellow in the Department of Molecular Pathobiology at NYU College of Dentistry and the study\u2019s first author."}